pgc 1α inhibitor sr 18292 (MedChemExpress)
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Structured Review
MedChemExpress
pgc 1α inhibitor sr 18292
Pgc 1α Inhibitor Sr 18292, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 77 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pgc+1%CE%B1+inhibitor/SR-18292/pmc13287963-99-3-6
Average 95 stars, based on 77 article reviews
Pgc 1α Inhibitor Sr 18292, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 77 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pgc+1%CE%B1+inhibitor/SR-18292/pmc13287963-99-3-6
Average 95 stars, based on 77 article reviews
pgc 1α inhibitor sr 18292 - by Bioz Stars,
2026-09
95/100 stars
Images
1) Product Images from "α7nAChR agonist GTS‐21 ameliorates sepsis‐induced acute kidney injury via MEF2/PGC‐1α/HO‐1 axis in mice"
Article Title: α7nAChR agonist GTS‐21 ameliorates sepsis‐induced acute kidney injury via MEF2/PGC‐1α/HO‐1 axis in mice
Journal: Clinical and Translational Medicine
doi: 10.1002/ctm2.70726
Figure Legend Snippet: α7nAChR knockout reverses the protective effects of GTS‐21 against LPS‐induced injury in HK‐2 cells. (A) Validation of α7nAChR deficiency in HK‐2 cells. (B) Representative TEM images of HK‐2 cells. Scale bar = 2 µm. (C–E) Effects of α7nAChR on MMP, mito‐ROS levels and apoptosis in HK‐2 cells. (F–J) Representative Western blot images and quantitative analysis of CytC, MEF2, HO‐1 and PGC‐1α in HK‐2 cells. (K–M) mRNA expression levels of MEF2, HO‐1 and PGC‐1α in HK‐2 cells. Data are presented as mean ± SD. * p < .05, ** p < .01.
Techniques Used: Knock-Out, Biomarker Discovery, Western Blot, Expressing
Figure Legend Snippet: α7nAChR knockout reverses the protective effects of GTS‐21 against LPS‐induced injury in mRTECs. (A) Validation of α7nAChR deficiency in mRTECs. (B) Representative TEM images of mRTECs. Scale bar = 2 µm. (C–E) Effects of α7nAChR deficiency on MMP, mito‐ROS levels and apoptosis in mRTECs. (F–J) Representative Western blot images and quantitative analysis of CytC, MEF2, HO‐1 and PGC‐1α in mRTECs. (K–M) mRNA expression levels of MEF2, HO‐1 and PGC‐1α in mRTECs. Data are presented as mean ± SD. * p < .05, ** p < .01.
Techniques Used: Knock-Out, Biomarker Discovery, Western Blot, Expressing
Figure Legend Snippet: MEF2 contributes to GTS‐21‐mediated upregulation of PGC‐1α and HO‐1 in HK‐2 cells. (A) Representative TEM images of HK‐2 cells. Scale bar = 2 µm. (B–D) Effects of MEF2 deficiency on MMP, mito‐ROS levels and apoptosis in HK‐2 cells after LPS stimulation. (E–I) Representative Western blot images and quantitative analysis of Cyt c, MEF2, HO‐1 and PGC‐1α in MEF2‐deficient HK‐2 cells following LPS stimulation. (J–L) mRNA expression levels of MEF2, HO‐1 and PGC‐1α in MEF2‐deficient HK‐2 cells following LPS stimulation. Data are presented as mean ± SD. * p < .05, ** p < .01.
Techniques Used: Western Blot, Expressing
Figure Legend Snippet: MEF2 contributes to GTS‐21‐mediated upregulation of PGC‐1α and HO‐1 in mRTECs. (A) Representative TEM images of mRTECs. Scale bar = 2 µm. (B–D) Effects of MEF2 deficiency on MMP, mito‐ROS levels and apoptosis in mRTECs following LPS stimulation. (E–I) Representative Western blot images and quantitative analysis of Cyt c, MEF2, HO‐1 and PGC‐1α in MEF2‐deficient mRTECs following LPS stimulation. (J–L) mRNA expression levels of MEF2, HO‐1 and PGC‐1α in MEF2‐deficient mRTECs following LPS stimulation. Data are presented as mean ± SD. * p < .05, ** p < .01.
Techniques Used: Western Blot, Expressing
Figure Legend Snippet: GTS‐21 ameliorates mitochondrial damage and promotes mitochondrial biogenesis in CLP‐induced mice. (A)Validation of α7nAChR deficiency in mouse kidney tissues. (B and C) Effects of GTS‐21 on survival in CLP‐induced mice. ( n = 6) (D) Effects of α7nAChR on serum creatinine levels in CLP‐induced mice. (E) Representative H&E‐stained images of kidney tissues from CLP‐induced mice. Scale bar = 50 µm. (F) Representative TEM images of mitochondrial ultrastructure in kidney tissues from different experimental groups, including Sham, CLP and CLP + GTS‐21 mice. Scale bar = 2 µm. (G‐J) Effects of α7nAChR on serum levels of NGAL, IL‐1β, TNF‐α and IL‐6 in CLP‐induced mice. (K–M) Effects of α7nAChR on MMP, mito‐ROS levels and apoptosis in CLP‐induced mice. (N–R) Representative Western blot images and quantitative analysis of CytC, MEF2, HO‐1, and PGC‐1α in CLP‐induced mice. (T‐U) mRNA expression levels of MEF2, HO‐1 and PGC‐1α in CLP‐induced mice. Data are presented as mean ± SD. * p < .05, ** p < .01. ( n = 3mice per group).
Techniques Used: Biomarker Discovery, Staining, Western Blot, Expressing
Figure Legend Snippet: GTS‐21 ameliorates CLP‐induced injury in mice in a MEF2/PGC‐1α/HO‐1‐dependent manner. (A) Effects of MEF2 deficiency or inhibition of PGC‐1α and HO‐1 on survival in CLP‐induced mice. (B) Effects of MEF2 deficiency or inhibition of PGC‐1α and HO‐1 on serum creatinine levels in CLP‐induced mice. ( n = 6) (C) Representative H&E‐stained images of kidney tissues from CLP‐induced mice. Scale bar = 50 µm. (D) Representative TEM images of kidney tissues from CLP‐induced mice. Scale bar = 2 µm. (E–H) Effects of MEF2 deficiency or inhibition of PGC‐1α and HO‐1 on serum levels of NGAL, IL‐1β, TNF‐α and IL‐6 in CLP‐induced mice. (I–K) Effects of MEF2 deficiency or inhibition of PGC‐1α and HO‐1 on MMP, mitochondrial ROS levels and apoptosis in CLP‐induced mice. (L–O) Representative Western blot images and quantitative analysis of MEF2, HO‐1 and PGC‐1α in CLP‐induced mice. (P–R) mRNA expression levels of MEF2, HO‐1 and PGC‐1α in CLP‐induced mice. Data are presented as mean ± SD. *p < .05, **p < .01. ( n = 3mice per group).
Techniques Used: Inhibition, Staining, Western Blot, Expressing